My opinion regardless of if you are tuning for race gas / 93 octane / alky or any other fuel are you need a standard set of tools / patience & common sense.
I think if you can get your self a good EGT guage / A/F meter and a set of electronic ears. These of course accompanied with the vital monitoring guages oil pressure, water temp, fuel pressure, boost should allow you to tune safely along with a safe place to put your car through the paces shouild allow you tune your car.
You can probably do a search and find what the relevant fuel pressure / oil pressure / water temp readings are if you don't know them. As far as EGT I have yet to find the average number for that. I am going to guess no more than 1550 - 1600 degree f. With A/F I have learned that the best power comes in the 12 - 12.5 range. I think most run a little richer than this though as a safety parameter. Not only does the fuel stop detonation from taking place but it also has a the ability to cool. Which we know detonation is a by product of heat.
So with all that said, I think you said it. Each car is different, I can get my eclipse to idle @ 15 / 1 a/f while the buick stumbles and needs more like a 12.5 - 13 to 1. So take your time and just move through the paces to find out what your car likes.
Oh yeah, I think most are of the mind set that boost over timing is going to yield more torque and power. So when runnin big boost numbers you want to keep the timing down. I think I have seen quite a few post indicating anything above 20 lbs = 17 degrees @ top of 3rd gear as an average. But again detonation is going to be your personal indicator. So you need to start low and slow and build up.