The most sure-fire way to get rid of detonation is to install a methanol injection kit. But there are plenty of guys out there running safe boost without the aid of methanol, so if you want to get rid of knock without the expense of an alky kit, here's a few tips:
Invest in an RJC power plate. It helps to evenly distribute incoming air to all 6 cylinders. When boosting, air slams to the back of the intake plenum and floods the rear 2 cylinders, leaning them out and causing knock. The power plate is designed to prevent that from happening and stop the rear cylinders from leaning out. I installed one and immediately noticed less knock. Some people argue that the plate is a restriction to air flow but I'd rather have evenly distributed air flow at the cost of a slight restriction to flow. Increased air flow is no good if it chooses to flow into the 2 back cylinders.
Play with the adjustments built into the TT chip. You can add fuel and pull timing. Pull all the timing it allows just to see if it helps. If it does, slowly increase the timing again unti you see knock. You don't want to pull more timing than neccesarry. Add a little fuel too. Adjust for 3rd gear, most knock occurs in 3rd.
Check all vacuum lines and turbo hoses to make sure unmetered air isn't getting in anywhere and leaning things out.
In my experience there's no magic fix for detonation. With each attempt you'll lessen it by a little bit. I didn't have the satisfaction of knowing detonation would stay at ZERO until I bought the alky kit, but the methods mentioned above did lessen it a little at a time.
