There is really only two downsides to running injectors that are bigger than you need...
1. At low engine loads like idle or low speed cruising, a big injector may not atomize the fuel quite as well as a small injector. This might hurt your fuel economy, engine smoothness, and emissions under these conditions.
2. At lower engine loads, big injectors tend to operate at very low pulse widths. At these low pulse widths, the injectors tend to be very non-linear in their response. What I mean is that at low pulse widths, changing the pulse width by a certain percentage does not result in the same percentage change in fuel delivery. Example: increasing the pulse width from 20 to 25 ms (25% increase) will result in an almost exactly 25% increase in fuel flow. However, increasing pulse width from 2.0 to 2.5 ms (25% increase) will almost certainly not result in an exactly 25% increase in fuel flow. The bigger the injector, the lower the pulse widths get, and the bigger this non-linearity problem becomes. Also, the lower the pulse width, the more sensitive the fuel flow response becomes to small changes in applied voltage (ie the system voltage). The explanation for this gets a bit hard to explain while typing on my phone.
Regarding Item 2, well, it's up to the chip maker to put things in the programming and tables to account for this. Having burned a few chips in my time, I have some ideas on how this is done, but the experts know a lot more.
Honestly, the injector technology and skill of the chip burners have gotten so good that running injectors that are way too big for your combo is now generally OK, IMO. I would buy injectors that will cover whatever your possible plans are (within reason, I wouldn't go right to 160-lbers) get a good chip to match, and be happy with it.
Mike
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