You'll get some different opinions on this..... but......
IMHO,
Oncenters are "generally accepted" as being able to support the most HP potential.....due to the fact that the piston is centered directly above the rod journal hence the term "on-center".
I believe up to somewhere over 1000 HP...... either will be just fine...... but at some (HP) point...... the people spending the $$.... just don't use a off-center block.
The "advantage" of using off-center blocks..... is you can re-use most of your stuff off your 109 motor..... like intake.... possibly headers....accessory brackets.... etc. On-center stuff is a different animal. Most max effort off-center motors use 4-bolt mains.... and have provisions for 14 bolt heads..... as opposed to the 109 with 2 bolt mains.... and 8 bolt heads....
HTH