If you are using a USB to Serial port convertor, then you need to check your Device Manager and make sure it is assigned to either Com 1, 2, 3, or 4. Then go thru your C-Com software and make sure it is assigned to the same port in there. You should be able to connect then. If you are still having issues, it maybe your cable. Not all USB convertors work with FAST, by what I have been told.