Ideally, for the best imaging...
You would want all your speakers as close together as possible. Also, you want the pathlengths from either side as equal as possible ( to both driver and passenger).
One thing you could try ( I have never seen a CSII setup, so I am not sure if it would work), is to build a thin "bridge" for the tweeter over the 5.25" driver in the door. This seems to work well in door mounted applications. If you make it out of a mildly thin metal, and dampen it, you could bend it to get the imaging where you would want it. But, this is all assuming there is room enough to do that behind a CSII panel.
Also, it depends on the tweeter material for the way it sounds. Cheaper tweeters tend to be more "abrasive" sounding, than silk dome ones, which are more expensive.