Yeah need to know more about the size of cam. Just my $0.02, but I have cyl press traces showing that the exh probably needs help blowing down on a high flow turbo v6, and widening the lobe sep does just that, gets the exh open earlier for a given icl. There should be no downside to that. As for advancing it, that will make a noticeable difference in bottom end on the turbo v6 IME. We've tried it several times now on various combos and it does the same thing each time, namely comes up better and feels a bit more responsive. The tradeoff is probably that you close the int earlier which is not good for top end. It all depends on what your intended rev range is and your converter and all.
FWIW I had a 224/224/110 solid roller in my 274"/GN1's street v6 for starters. Installed well advanced at about 104 icl. With a T76/.81 4 bolt q trim it made 30+ psi boost. It came up very well and was very responsive. Idled at about 17 in Hg, so obviously favorable to the low end. Ran very well, but the combo dictates more rev range, needs to go to about 7200 rpm. Of course if you're only going to rev to say 6200-6300 or so then a 224 range stick is probably plenty.
Fast fwd to recently, put in a new 242/242/114 solid roller, installed on a 110 icl. Along with some much stronger pushrods. This cam gets the intake open in nearly the same place as before, but hangs the int open some 15+ deg longer. Also gets the exh open some 15+ deg earlier, yet still closed by ~ TDC.
Results so far, it went ~ 4 mph faster than before in the 1/8th mile on the 1st pass, through a closed single 3" exh, at 4 psi LESS boost I might add

Now the same turbo only makes 26 psi max. Target for now is 120 mph in the 1/8th and she's getting close already

Uncorking the exh and launching harder than a 0 boost, just roll it out 1.65 60' would put it there. The upside to the easy launches has been that the original stock rearend still looks ~ new inside after 15 yrs. No spline twist or damage, no anything. We changed posi clutch disks last week and just put it all back together for now.
Idles at about 12 in Hg, yet drives and idles fine IMO, considering the weekend warrior-type perf level and all. A 242 is maybe larg'ish in the turbo Buick scene I guess, but probably not so big really in the grand scheme of things. Not all radical like I feared it might be. Also still comes up great, the converter stalls to about 3700 and seems to be a great match for the combo. I like it, and obviously the engine does too

Note that I also use a little nawzzz assist in 2nd and 3rd gears.
Hope that helps somehow (?). JME and MO.
TurboTR