Your subs are rated to handle a total of 150w rms for the pair. Because they are in a ported box you don't want to grossly over power them either. If it were a sealed box I'd say go for it. I have found that ISO loaded subs have more excursion but not as much as a sealed box so ISO would only give a little more power handling. Not sure I'd put over twice what the subs are rated for on them in the ported or ISO box. I'd have no problems putting 200-250wrms on the pair in the ported box but more than that and you may burn the voice coils to easily. Why not bridge the rear channels of the Xtant on the subs giving them 200wrms and run the mids/highs on the front channels of the Xtant since you like how that amp sounds better? Even if your subs are 4Ω you could series them to 8Ω and run the gain twice as high on the sub channels as the highs channels.
Amps are rated to give different power at different impedance loads but the truth is that they will deliver their full power to any load. The output capabilities of an amp is determined by how much current the transistors can produce. Reducing the impedance of the speakers does the same thing as increasing the input gain to the amp as far as producing power goes. Both of these methods tax the output transistors for more current which produces more power. Keeping the amp with a load that it is designed to operate under is important to protect the internal circuitry of the amp but it can be worked around as well. You are always safe going up in impedance and compensating by adding input gain within reason. Run that Xtant at 8Ω bridged and the gains twice as high as the gains on the mid/high channels. One amp and a simple clean install that sounds good to you.
Hey Clay, I checked the specs on those subs and they are actually rated at 150W RMS each. I tried them in series bridged and it worked better, but they are severely underpowered. On top of that, they don't punch, but rather just resonate deeply. I was thinking about porting them higher to see how that worked, but decided to plug the ports just for fun to see what happens. All I can say is WOW!!!! They hit hard and tight, go deep, and are still musical. I tried one in a .7 foot ported enclosure and it sounded choked up, but they perform fantastic in the larger 1.3ft enclosure. I am going to work on playing with a second amp mounted to the front of the box so I can dedicate one to these.