Inevitably, as I push up the nitrous hit, a number of things are guaranteed to happen.
The hp level at the low/mid rpm range will increase. Shortening the 60 foot time. Surprisingly, calcs show that cylinder pressures will be safe all the way up to a 400 level shot (with alcohol). I'm sure that level will not be needed to obtain the target goal. Another interesting calc indicates a possibility of a 1.15 60 foot with the new rear tires.

Is that really possible?
Exhaust mass and energy will increase, shortening turbo spool time. The tuneup will have to be carefully studied at each shot level to make sure that the combination of nitrous and boost rise does not cause a breech of cylinder pressure limits around peak torque rpm. This will make boost control during the initial launch very critical.
As turbo spool up time decreases, the required nitrous on-time will also decrease.
The torque converter stall speed will increase with each step up of the nitrous hit. Calcs indicate that with a 346 shot, stall speed could be over 3900 rpm using the present torque converter.
So, with different levels of nitrous I am doing two different tuning operations that would normally require changing of components to accomplish without the nitrous.
I am changing the spool up time that would normally require a change in the whole exhaust system and/or a change in the exhaust turbine housing size and/or a/r ratio. Or, having to compromise with a smaller overall turbo.
I am changing the stall speed of the torque converter that would normally require trying to match the correct torque converter to my particular engine combination. A shot in the dark at best and ultimately ending up with a compromise situation.
I can accomplish those two, very critical tuning operations simultaneously with the simple changing of some jets. And some think running nitrous makes things too complicated?