also, they have a 2 bar map sensor(vs buicks 3 bar). So 14.7 psi is all the computer can read. Chips are much more expensive and did I mention more difficult to work on

I have a vid of a 4.3 making 700 hp on 91 octane and meth injection,,,,, not bad!
The stock chip and 90's aftermarket chips are 2 bars, but any decent aftermarket chip is 3 bar. The stock IC isn't that bad as long as it work properly, with Alky you see MAT's below ambient.
Weak points, yes on the transmission, stock internals of the engine, also the ignition components need replacing often.
The transmission just doesn't hold well to 500ft-lbs+ modified truck make. Anything but the smallest turbo upgrade will need a built up tranny, so basically if your appraoch 11's be praper for a tranny. $l80E are available and nearly indestructible for all but the Hgh HP motor, but they are $5000+.
Internals- The stock motor is a run of the 4.3 with hypereutic dished pistons & nodular main caps. The can be pushed into the 11's, stockers don't blow headgaskets, they melt piston and through rods. A built motor can remedy this. Stock motor can do 11's, one guy pushed his to 10.9's with a small shot of N20 (he was running 11.1 without it) He did it with stock cam & heads as well. The key is key the revs down and concentrate on the tune & adding boost. The stock heads are detonation prone, the stock chip is set for 14 degree timing

Vortec head conversion allow much more timing to level your guy are used to seeing.
This ignition cap/rotor/plugs seem need replacing with the oil changes. The LC2 ignition is light years ahead of these trucks. Their is LS1 coil conversion, but I don't know many people using it.
The AWD is cool for a street vehicle. 400rwhp & 600+ ft-lbs of torque will actually hook up in the lower gears on real street tires that could driven accross the country and back. They aren't the fast thing at the track, due to the AWD limitations, but they are quite formidable on the street, especially if you catch any RWD vehicle in street trim. They aren't nearly as well know as GN's so they don't atrack much attention. They have more unique parts than a turbobuick. They are finicky due to its ignition.
The ECM is further advanced than the turbobuick ECM, but since its MAP based it doesn't compensate without changing the tune for major changes. The TB buick ECM's simplicity makes for far easier tuning. Just recently the their has been major overhaul of the ECM's code done by enthusiast, it has the functionality to compete any Aftermarket EMS, it just doesn't have the nice interfaces they do. If your into tuning, getting your hand dirty work on them, they can be very fun and rewarding. A lot of the people who own them are like that as well. If your going to fix the above weak points to make them bullet proof, they can be very expensive. If you want to get into something and drive then they aren't the best daily driver.