Last year I re-cored my radiator with a CAS high efficiency. When I refilled it I used distilled water and RMI. When the cold weather started to come around October, I drained it, flushed it, and added distilled water/anti-freeze plus a bottle of RMI.
The water/RMI came out clean as a whistle in the fall. I've been too lazy to drain the antifreeze mix this summer. My temps have been just fine. I've never seen over 182 deg F...even in traffic with the A/C on Max...normal temps with that A/C off are 168-170.
Nick Micale will tell you that the water/RMI mix is the best for heat transfer. I'm doing just fine with antifreeze/water/RMI, and it's been pretty hot here in Oklahoma.
The glycol in antifreeze never "wears out". A new bottle of RMI once or twice a year will keep the additives fresh. So, basically, do what you want. If you have the time/patience to change the fluid as the weather changes...go for it.
Good Luck,
John