IMHO, you can't beat Glock for *out of the box* reliability and accuracy. I've owned many different pistols including Berettas, Sigs, Colts and Rugers in .40, .45, .380, .38, .357 mag and 9mm. After cycling through quite a few, I finally settled on a Glock model 22 and I've carried it almost every day for years now.
Rob
Rob