Boost Reference..
Two things, really. As stated above, the control scheme for maintaining fueling is much simpler when the injectors have a constant differential pressure. Otherwise, as the boost goes up, injector would pass less fuel, and since the "closed loop" is not used for WOT, the chip would have to be programmed to increase pulse width. Since the chip doesn't know what the boost is, that would be tough.
Second, the injectors are almost all designed for a diff. pressure of about 45 psi. If you get too far from the design dp, the spray pattern gets messed up. So, the pressure regulator takes care of the problems.. until it starts to screw up.