What I'm trying to ask is that say you have a small turbo at 25psi running a certain ET and it takes 20psi to run the same ET on a larger turbo. The 20 psi I would think would be easier on the deck of these engines were they are prone to crack. Just my thoughts.
Thats only because the larger turbo in your example is more efficient than the smaller turbo. They are producing the same volume of oxygen, one just needs more psi to compensate for the heat it is imparting on the air which makes the air less dense. It also makes air molecules spread out which is why you can see more boost with the same amount of air if it is heated. Like a nitrous tank, if you heat it, pressure will rise even though the amount of nitrous in the tank didn't change.
If they (small turbo/big turbo combos) run the same times they are generating similar cylinder pressure during combustion.
The danger to the engine in running the smaller turbo lies in the heat it is imparting on the inlet air. This will make the engine more detonation prone and that is what breaks things.