Ethanol is another alcohol. Not as good in a high performance application as methanol, but it's attraction is price. E85 has pump gas mixed in with it making detonation a possibility if mixtures aren't right. I'm not even going to get into the varying percentages of pump gas that you have to keep on top of with the stuff. Detonation being preferred over preignition if you're unfortunate to have either. Alcohols will typically skip the detonation mode and go straight to preignition. Preignition is not good on parts. If alcohol goes into preignition, the damage can be very quick. My second engine that I blew due to a mis-match of a/f mixture strength, static CR, boost, and the wrong spark plug happened to bend a mighty Carrillo right as the car left the line. The front end was rising, then bang! No pinging. No warning. Just a big bang, then clattering as I rolled the car to a stop. The tell tale sign was a melted ground electrode from one of the rear cylinders. The conditions got the ground electrode hot enough to preignite the mixture. The rod came out looking exactly like James'. Bearings and crank journal were fine. In fact, I'm running the same crank in the present build.
Every blown engine has a lesson to teach. Ignore the lesson and you risk having the lesson repeated to you. I have been one of the luckier alky burners. It only took two blown engines for me to learn respect for the fuel. Some will go through a storage unit of blocks before they get it figured out.