If you've eliminated the valve covers.. and other simple leakage stuff from the outside..
Guides in my experience as long as the following other stuff has been looked at: If you have a blowby prob, or PCV probs - is the intake plenum area coated with oil from the crankcase or possibly a bad turbo seal? If you have an RJC power plate you can just pop off the throttle body pipe and look through the open throttle. If it's coated with oil, this could be part of the problem. It's easier to see with the plate because it tends to pool along the back edge of the plate.
If the motor sits for a while, and you start it back up, does a bit of blue smoke come out the exhaust? If someone else is driving the car and you let it coast a bit, does it puff a bit of blue on decelleration?
Lots of stuff it could be, but if the motor has some miles on it, and some of the other stuff above has been checked off, I would think guides.
I never did it on a turbo Buick motor, but have had mixed results with teflon seals on the heads on other motors that were NOT force inducted..
If you have stock heads and a pretty mild setup, the way the car came from the factory with seals on the intake and nothing on the exhaust works pretty well in my opinion. It lasts a long time.
Billy