Don't see this mentioned much. But it can be a big deal 
The cam I have currently is .380" lobe lift, Comp Extreme Street profile lobes. The lobes come out fairly close to the cam journal diameter, like many rollers do. Crank has a 3.625" stroke. The rods are custom billet 6.25" Olivers, wide journal, on center. The one side where it might otherwise contact the cam lobe (right where the rod bolt would poke through the top) is shaped differently for stroker clearance to the cam lobes. It has a "flat" area there. Sounds good, the rods have been designed for stroker clearance and we are good to go, right? But in mine, with that Extreme Street, high lobe lift profile cam there was only about (roughly) 0.040" clrnc from the lobe tip to the flat area. It matters a bit where the cam lobe centerline is installed of course, etc. It's kinda tough to measure, but if you remove the piston next to a trouble cylinder you can reach down in there and get a small wire feeler gauge in, while also holding a mirror, a flashlight, standing on your head and speaking in tongues to the BMS gods, etc (lol).
BUT a sneaky upgrade to the problem- the high dollar, indestructo rod bolt$ in the high dollar rod$ (lol) do just barely poke through the top of the flat area. We're talking like 0.020-0.025" or so. But that also brings the rod to lobe static clrnc down into the 0.02x" range, roughly... Waaayyy too close for comfort, needless to say...
So heads up for anyone running a 3.625" stroke or even a 3.590" for that matter, and a high lobe lift cam, even if the word "Street" is attached to the profile description Or any cam that comes out near the journal diameter I guess. Especally like if you swap to a bigger cam from the one the engine was built with (carefully of course, assuming it had adequate clrnc originally 
TurboTR
The cam I have currently is .380" lobe lift, Comp Extreme Street profile lobes. The lobes come out fairly close to the cam journal diameter, like many rollers do. Crank has a 3.625" stroke. The rods are custom billet 6.25" Olivers, wide journal, on center. The one side where it might otherwise contact the cam lobe (right where the rod bolt would poke through the top) is shaped differently for stroker clearance to the cam lobes. It has a "flat" area there. Sounds good, the rods have been designed for stroker clearance and we are good to go, right? But in mine, with that Extreme Street, high lobe lift profile cam there was only about (roughly) 0.040" clrnc from the lobe tip to the flat area. It matters a bit where the cam lobe centerline is installed of course, etc. It's kinda tough to measure, but if you remove the piston next to a trouble cylinder you can reach down in there and get a small wire feeler gauge in, while also holding a mirror, a flashlight, standing on your head and speaking in tongues to the BMS gods, etc (lol). BUT a sneaky upgrade to the problem- the high dollar, indestructo rod bolt$ in the high dollar rod$ (lol) do just barely poke through the top of the flat area. We're talking like 0.020-0.025" or so. But that also brings the rod to lobe static clrnc down into the 0.02x" range, roughly... Waaayyy too close for comfort, needless to say...
So heads up for anyone running a 3.625" stroke or even a 3.590" for that matter, and a high lobe lift cam, even if the word "Street" is attached to the profile description
Or any cam that comes out near the journal diameter I guess. Especally like if you swap to a bigger cam from the one the engine was built with (carefully of course, assuming it had adequate clrnc originally TurboTR
