In over 30 years working on and dealing with turbo Buicks, I have not found, or even heard, one "legitimate reason" verifying any benefit when switching to synthetic oil in this 1960's designed V-6?
Have seen many 150K+ turbo Buicks running well with the original, un-opened engine and original turbo that have always been operated with regular oil.
There are some downsides to synthetic oil other than cost, and one main one is it drains off bearings and cylinder walls in a few days of non-use. Conventional oil will stay in place to eliminate dry starts.
Just my opinion and experience, your $$$, so spend it as you see fit!