You don't an intercooler if you run E85 and Alky. I run 25psi and 25 degrees of timing without issue, that's plenty for me.
The turbo will wake up big time, I have a post about it in the E85 section and it's crazy how much the car woke up. I had to turn out the boost controller completely after turning out the adjustable wastegate rod and the boost controller a ton, I was baffled.
Eric eventually trimmed out 30% in my 80lb injectors for me, I run 32gph of Meth (2gph preturbo) so the car needs to run no leaner than 10.2 after doing some crude calculations. Before the year ended I had the car at 10.2 in 3rd at 25psi and 25 degrees, I'll add 5% in 3rd and probably trim out 5 or 10% in 1st and call it a day.
I can easily run the TA49 to 32psi and probably still pick up MPH, but I've had a hell of time the last 5 years with this car so I'll work on driving it more in 2011 and keep from wrenching on it.