How can you assure each cyl gets the same amount of methanol, with one nozzle in the pipe 12" away.
You can't. That's why port injection is so nice.
What you can do to
minimize distribution problems with a single nozzle will be to get the best quality of atomization and nitrous/fuel mixing at the nozzle, and set the distance of the nozzle so that the mixture has time to convert, as much as possible, to a vapor before the mixture has to make any drastic turns. Vapors have a much easier time making a turn than droplets do.
I'm not sure what distance the single nozzle kits suggest, but when I put my single nozzle kit together, I will be doing some simple tests to see how far it takes for the mixture to mostly vaporize. I think Scott (Chevota) may have figured out a good distance for nozzle to vapor distance with his truck. Maybe he'll chime in with that. That distance could also be different for different nozzle designs.
Anyway, you will never be assured perfectly equal distribution from a single nozzle. You'll notice that plate systems are constantly evolving, because of the endless search for better distribution.
A single nozzle system is good for small hp shots. Any distribution problems that result from a small system are managable. As the system hp number increases, distribution problems become more acute. That's why you see big systems always being port injected.
Dry single nozzle systems can be less of a problem as far as distribution, because you don't have to worry about fuel fall out, but the port injector system must accurately add the required amount of extra fuel to burn with the nitrous at the right time.
I would also experiment with pointing the nitrous nozzle into the oncoming flow of air to help the mixing. It might be best to consult with the manufacturer of the nozzle first.