Don't know if this will qualify as "insight" but we have looked at a few failed Buick cams. The others that examined them with me are very experienced in race motors both in building and tuning. The premature cam failures which happened within a few thousand miles or so, all so all indicated a bad core. Mainly the heat treat, hardening process, was not done properly or deep enough.
One in particular we know was broken in "by the book" was showing signs of wear in less than 1000 miles. Lifter looked fine, lobe was worn and had small imperfection on the surface. This was certainly NOT due to spring pressure [~100#'s], but a bad core.
We do a 20-30 minute break in run, but within a few minutes the lobe and lifter become acquainted! Like was already said, cam lube is gone, so they are on their own from there for better or worse.
Few years ago, there was a rash of aftermarket Buick cams with low mileage problems and most were found to be a core problem. Some people have said the lifter bore alignment is off on some blocks. But if it runs fine for 100K miles or so on a stock cam, and 1000 miles or so on a replacement cam, would seem no block problem?
As far as an answer to your original question, think I would direct it first to the cam supplier/manufacturer.
This is strictly my opinion, but I feel the "improper break-in" reply to a bad cam is voiced so much from the suppliers/manufacturers, that it has become "the reason". Second excuse, "wrong valve springs".

They would NEVER put out a "bad" product!