My carry is a 25 ounce 45 and I have always thought bigger is better. I now would like to have more comfort and better concealment and I may go to a 380. Remember a .22 will kill your ass quick. They do everyday. I like having more rounds also. I shoot well, but have never had to shoot a human being while under duress. It is easy to miss your target. Those extra rounds may come in handy.
The op posted about ammo and I was at a shop the other day and saw 8 rounds of 380 going for $24. It claims to have more knock down power than a 45. How with less powder and lead? I dont know, but its worth researching.
I think the new ammo technology is changing the big caliber carry mentality some. Its got me thinking.