Ya, a lot of people are making the move, but I suspect a goodly number for the wrong reasons. Running the Translator Pro is a good part of both worlds, and I personally wouldn't make such a move, nor do I see the need. I mean after all, you have all the complex overhead being taken care of by the stock ECM for idle, cruise and general driveability issues, and when it comes to WOT, I don't see how the TPro can be bested. After all it has a huge VE table that you can play with just as the FAST systems have. And if you don't like playing with individual cells, then there's the user tune tables that can adjust larger sections of the VE table. And don't forget the TPro allows you to control a second fuel pump if needed, can adjust boost at two levels (mine is gear based) with the aux input, and another level of fuel control with the aux input if desired. ETC. ETC. ETC.
Now, with all that said, the one thing that I've noticed that the stand alone SD systems have as a huge advantage would be their software implamenatation. We have to use TunerPro which is extremely limited and weak kneed compared to the other stand alone systems like XFI, and Mega Squirt 3. I've had the chance to play with MS3's software (can't remember the name) but it's really slick when in comes to making changes on the fly to the VE table.
If anything were to drive me away from Translator Pro it would be the TunerPro software, but..... I don't see that happening simply because I don't want to be strapped with the misery of having to make all the other dozens of adjustments in overhead stuff to try and get the car's street manners as perfect as I like them. I demand perfect driveabilty because mine is a street car, not a dedicated race car. I have that perfect driveability with my present system.
Now, if you need some of the fancy Buck Rogers stuff that the standalone systems offer, like traction control and stuff, then maybe it's worth a look. But is your car that serious a drag racer that it needs any more fancy stuff that what you now have with Tpro??