well it all comes down to potential.
the 4.1 has a bigger bore. which in general equals bigger engine, which if you go by the ol'standby - there is no replacement for displacement.
I see it as a bigger bore that offers less valve shrouding. which equals better breathing, which makes more power.
the downside? well the 4.1 has a weak deck.... and headgaskets are a buicks nemisis..... so the weak deck offers little to help in the clamping of the head. most would say a 4.1 block is good to about 450-500 hp..... but then your on borrowed time.
the main advantage is, it doesnt have to work as hard to make the same hp number (though limited to 450-500) especially in a NA combo or a street driven engine.
A.j.