That is a good question that has not yet been addressed here on this board.
Most of my comments will be disputed by owners that drive their cars on the street and see minimal performance and RPM and have over 100K on their original engine. A billet cam means serious performance, and if some want to waste their $$$ on synthetic oil, they can do so.
First, Rotella is a diesel oil, and will work good for engine break in IF you add ZDDP for proper wear protection. There are 2 issues using Rotella for everyday driving in a performance Buick.
One, it has way too much detergent which counteracts the anti-wear additives.
Second, it is NOT formulated for high RPM use. My Cummings runs between 2000-3000 RPM, but mainly at the lower figure. At twice that RPM range, you will have oil foam which does not lubricate well.
Just to mention flat tappet cams going flat, this was a BIG problem in the late 90's, not just in Buicks, but all the aftermarket performance models. This was a cam problem in most all cases. In the hundreds of Buick V-6 builds we have done, only 3 customers have reported cam/tappet failures, and all used Mobil I.
A roller tappet cam, either hydraulic or solid, use more spring pressure and sees more RPM than a flat tappet. [And more often!:biggrin:]
The wheels and small roller bearings see LOTS of pressure/loading which can and does cause failure. I have also seen the billet cam lobes with excessive wear.
With all that said, why would you NOT want the best lubrication/protection for an engine build in the $10K+ range?
There are now many speciality oils for performance engines, or just a good brand and add ZDDP for less $$?
Since the "benefit" of synthetics oil is longer time between changes does not fit a performance engine, especially one with forced induction, you are much better off changing the contaminated oil after 1000 miles or so.
I know others will have a different opinion, but this is what has worked for me and many of my customers over 25 years in the turbo Buick world!