If you want 13's just build a mild small block with a forged bottom end, or get yourself one of those GMPP crate motors and then drop a 125 shot on it....whatever get's you to the 400-450HP range.
A well built 10 bolt with the right gears will handle the power. A prepped TH350 or Powerslide, the right converter, sticky tires....should be in the low 13's all day long and consistent as long as the driver has skills. High 12's if you have good RT and 60's.
The only time squeeze is going to be inconsistent is when you let the bottle run low or don't control the bottle temp and pressure.
The only time it'll hurt your engine is if you don't install it correclty, keep tings out of tune, let it lean out or try to use more of it than you should, but most mild built engines can handle 100-125 shot quite safely IMHO, and you can get systems that are pretty much bolt on and play.
Tim
SWEETT!! You guys rock!! I do have some racing skills..

I still dont like NOS... but.. Ill keep that in mind.. 100 shot shouldnt hurt... good info to know...