This is a very important topic. If you really want to dial in your nitrous system, pay attention to this.
This may not be as important with a small shot size, since the motor will tolerate a small lean or rich spike during the moment that the nitrous system activates, but as you go larger with the system, this topic does gain importance.
This pertains to wet systems.
The best positioning of the solenoids for a single nozzle setup would be to have the solenoids mounted right off the nozzle. This way, when they both activate, the fuel and the nitrous have a very short distance to travel before exiting the nozzle. The nitrous, being under much higher pressure, will begin spraying from the nozzle slightly sooner than the fuel, but the difference will be minimal. The further the solenoids are mounted from the nozzle, assuming that both are mounted the same distance from the nozzle, the more the time differential becomes in regards to the nitrous reaching the nozzle before the fuel. That creates a longer lean spike for the engine.
Hose diameters and lengths create resistance to flow. That's the way of the world and you can't get around that. If both solenoids are opened at the same time and the nitrous and fuel have to travel through 3 feet of -4 hose, the nitrous being under 950 -1050 psi pressure is going to get to the end of the 3 feet before the fuel, being under 8 or 45 psi pressure.
If you just can't mount the solenoids that close to the nozzle, you can use varying lengths of hose for each solenoid to change the timing as to when the two elements reach the nozzle. Of course, the nitrous solenoid would need a longer hose than the fuel side. We want to give the fuel side a head start since it is under much lower pressure and will be slower at getting to the nozzle. Another way to accomplish a better timing to the nozzle would be to control the opening of each solenoid separately or use a delay box to open the nitrous side slightly after the fuel side was opened. The idea with both methods being to make sure that the fuel and nitrous reach the nozzle at the same time so that we control the n/f ratio at initial activation as best we can.
A good example is my system. I have a spider distribution manifold that feeds to six fogger type port injection nozzles. Each nozzle delivers over 50hp worth of nitrous and methanol fuel flow. The fuel solenoid is mounted practically directly on the distribution manifold. The nitrous solenoid has a 3 foot hose between it and the distribution manifold. Even so, I get a very slight lean spike on initial activation of the system. Not enough to worry about making the nitrous hose any longer, but it just proves the point of how much faster the nitrous can get to the nozzle versus the fuel side. I've found that as I stepped up with the system hp level (larger jet sizes) I've had to go from a 1 foot, to a 2 foot, and now a 3 foot hose between the nitrous solenoid and the common distribution manifold.