I run 3 mufflers...2 Hooker Aerochambers (2.5") in the normal location for the aftermarket systems and a 3" Ultraflow where the cat would go. It's not much quieter, if at all, then with the cat in place instead. This is probably the case because the muffler in the cat location is too close to the motor. They say to make the car its quietest, the muffler(s) should be as close to the tail pipe(s) as possible. Regarless, by most comparisons, my car is pretty quiet. Most of the time, spectators say they can barely hear my car when I'm racing. As for backpressure, who knows. I run 115mph in the quarter with a TA49 so I'd think backpressure can't be too bad.
I too looked into putting a "crossflow" style muffler in the stock location in addition to the Aerochambers. However, no one seems to sell a good, low restriction crossflow muffler and both Dynomax and Mufflex said DO NOT run a dual in/out muffler (like Ultraflow 17231) with the gases running in opposite directions thru the two tubes. I was willing to pay Mufflex to custom make me a system that would use this style muffler in the stock location of my GN but they refused saying the muffler would destroy itself in no time.