What most of the guys are getting at is that the design wasn't intended to have that much HP. The stock crank will flex, the block will flex, the mains will try and move or crack, and the webbing will crack when all this happens. Even if you don't decide to go with an aftermarket/performance block you do need to go with a forged crank and aftermarket rods if you want it to live longer than the first WOT run.
Also at the 750 HP level you'll need to get a better drivshaft, 30 spline axles, and a new posi to go with it. Now let's talk suspension here. Boxed rear arms will be needed as well as a complete suspension overhaul if you plan on the car to do more than spin or break something else.
None of us are being mean here but at the 750 HP level you can't just throw the engine in, tune it, and expect things not to break, so you've got to upgrade everything, not just the engine.
And then there's the cost of saftey equipment the drag strip will require for any pass after your first 10.**......... I can't get anywhere near a 10.99 at my local tracks with out a bar, balancer, loop (which I have) and trans blanket because the car is too fast.
If your goal is a 10's capable car, your in luck.
I'm certain I would be lying if I said my car was 750HP, but deep, deep 10's with my Lou Czarnota built 109 are not a problem. Lou built me a pretty nice car, period. He is an incredibly gifted TR builder.
I've also asked you to listen to Nick Micale. Another great builder and mentor.
Bison and Charlie F are also extremely realiable guys when looking for advice and/or hands on building.
You have an abundance of knowledgeable guys here to help you!
Another poster said read, read, read.... he was correct.
As a side note, you won't reach 750HP on your own, even with all the knowledge, advice and tech on this board , not by yourself or with the help of your freinds.
If you really want to go there REALIABLY, enlist the help a pro.
When I bought my TR, I told my builder what I wanted and he worked with my budget and "bang for the buck" in mind.
I got what I paid for
A trans shop that can build a budget 1000 HP 2004R would be a God Send to this community, PLEASE tell us who he is!!!!
Perhaps you should look at the ET and MPH goal and go from there.
I can assure you, not many real street cars in Arizona would even stand a chance on any city steet or 1/4 mile track or 1/2 mile blast on a freeway against my car, but I'm biased.....
I surpassed your 10K mark by quite a bit, but I can say "bring it" to any real street car in the state with few worries.
Perhaps you should reconsider and set your goal to that which you really want to achieve on the street and strip instead of an arbitrary HP goal.
Good luck to you, sir!