Based upon both your statement and Chuck's, our experience has been about the same about cracking blocks before trashing cranks at the 600 HP level.
However a major factor contributing to block failure at the main saddle is crank flex.
A lighter, weaker cast crank will have LOTS more flex at the 600 HP level and RPM to develop that power than a stronger, heavier forged or billet crank. This has been illustrated in the many 600 HP engines we have rebuild as the main bearings will show extreme flex in their wear pattern.
We have many engines running 600 HP with forged cranks, no girdle, but 2 center caps, and this wear pattern in not shown there.
Even the best tune cannot counteract the fatigue factor of the V-6 stock crank or block, but minimizing crank flex by using a forged will go a long way to insure more longevity at the higher HP levels.
The rolled fillets on a cast crank does not improve strength, but helps to eliminate crank failure due to cracking
Even back further in time when working with the big block Buick V-8, it was evident well below the 500 HP level crank flex was a big issue as many blocks and cranks were trashed until the billet cranks were made for the V-8 which doubled their HP potential.